The Spireites aim to sweep aside their recent defeats as they travel to Oldham Athletic with plans to get their early season form back with a first away win.
In their path are a Latics side in similar circumstances league-wise after a summer of major upheaval at Boundary Park.
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Manager Danny Wilson said in his pre-match press conference that he has no new injury concerns ahead of the match, though Dan Jones
faces longer on the sidelines than expected as specialists get to the bottom of his injury problems.
Connor Dimaio returns to the Spireites fold after his international absence with the Republic of Ireland under 21s. The midfielder made two substitute appearances, at home to Slovenia in a 2-0 win and then away to Serbia in a 3-2 defeat.
For the Latics, midfielder Ousmane Fane misses the game through suspension after seeing red last weekend, while full-back Jamie Reckford also misses out due to a hip problem.
There's more positive news elsewhere for Saturday's hosts with Calaum Jahraldo-Martin and Cameron Dummigan in line for a return, be it from the bench or in the starting 11.
The match will also see the Spireites come up against former midfielder Ollie Banks, who was a key player as the Spireites won League Two and reached Wembley in 2014 before joining the Latics this summer.
Spireites fans will need little reminding that after a good start and seven points from nine, three defeats have since followed.
Wilson said after last Saturday's stoppage time AFC Wimbledon 2-1 defeat that if he has to go back to basics - as happened upon his arrival last season - then he would be willing to do that to ensure the defending gives the Spireites more chance for further points.
Oldham have faced similar struggles of late, with three losses and just a point from their last four matches in all competitions - the latest of which a 3-2 home reverse to Shrewsbury Town - and sit a point behind the Spireites in the Sky Bet league 1 table.
From the Dugout
With Oldham counterpart Steve Robinson facing all manner of squad changes during pre-season, Wilson commented on the difficulties the young Latics manager faces, as well as his own in scouting the opponents.
"You have to do a lot more homework on them, that's for sure," he said. "Because one or two of the players that they've brought in are from places where we've not seen too often.
"Generally we've got enough information to understand that the players they have will be very adequate at this level, if not pushing for a top area for their finish.
"For somebody to bring in 19 or 20 players is very tough, but at the same time they'll be his players and he can bring them in say that it is his team now - with not many of the lads there last season left, and he can mould them however he wants."
Wilson saw a signing of his own, Conor Wilkinson, impress on debut last Saturday, and spoke further about his new striker.
"He's a player who is a confidence player," he said. "He's one of these players that needs an arm round him and we'll give him that - as well as some tough love at times if it's necessary.
"Overall, he'll be a good addition for us, we wanted that extra striker in there after letting Sylvan go out on loan and we feel that he has goals in him at this level. We've seen him at this level before and we know that he can score and the quicker he does that with us the better."
You can keep up with all the movements in Lancashire on Saturday with commentary of Spireites PlayerHD, as well as full coverage across Twitter, Facebook, Instagram and the official website during the match and across the weekend.