The Spireites are in need of a lift and have the chance to knock off the league-leaders on Saturday as Scunthorpe United visit North Derbyshire.
In a tight division the Spireites find themselves in the bottom four but would receive a huge boost if they were able to upset their familiar Lincolnshire foes.
Danny Wilson has confirmed that striker Conor Wilkinson will be out for up to two months with the knee injury he sustained last weekend against Southend, so won't make the game.
Returning duo Ched Evans and Paul McGinn were risked for the Fleetwood match in midweek, with Wilson saying that one of them has since had an injury setback - though the manager refused to say which of the two players was concerned.
Liam O'Neil and Dion Donohue have both come through two games in a week after their injuries and are expected to continue in the full-back berths for the Iron's visit the Proact.
Luke Daniels is a doubt for Scunny with a head knock and will be given the chance to prove his fitness ahead of kick-off. Luke Williams, Jordan Clarke and Harry Toffolo will definitely miss the Proact visit with their own injuries.
The Spireites have managed to pick up just a point from the last 15 on offer in a run of form that has seen them slide down the table after a positive start to the campaign.
There has been little to upset the Iron so far in 2016/17, sitting atop of the table and three points clear - however, they did have a hiccup in midweek as Oldham Athletic claimed an unexpected 2-0 win against them at Boundary Park.
Scunthorpe are the league's top scorers and in winger Josh Morris alone have a player who's netted 12 times already this season.
From the Dugout
Speaking before the game Spireites defender Sam Hird was bullish in his appraisal of his side's chances of causing an upset in front of the home fans.
"I do believe in this league that on our day we can beat anybody," said Hird. "This is with no disrespect to Scunthorpe on anybody, but there aren't a Bristol City in this league and if you are able to put two or three wins together that's the key to being successful.
"Barring Tuesday night that's what Scunthorpe United have done so far. Like most sides at the top of the league they're scoring goals, so first and foremost they've got fire power.
"I've played against Paddy Madden quite a lot in my career and he's a great striker, especially at this level where he scores goals and works hard. Van Veen up top and Josh Morris on the wing, have contributed well with goals this season.
"We've got to try our best to stop that, whilst also putting the ball in the net at the other end, which is something we've struggled of late with."
Hird explained further that he and his team-mates won't mind being unfancied for the match, with confidence still high in the Spireites' dressing room.
"Even though we're at home people will see us as the underdogs because of where Scunthorpe are in the league. We don't mind that, we're a confident group so the morale's not as bad as people might think.
"We're all geeing each other along, training's sharp and we're looking forward to the game," he said.