After Monday's encouraging performance, Danny Wilson's Spireites look to build as they face Shrewsbury Town at the Proact in their first fixture of 2016.
The 1-1 draw with Coventry City in Wilson's first match showed an increase in confidence among the Spireites squad and the home fans will be hopeful of seeing that progression continuing.
The game will also be the first with the new management duo of Wilson and incoming first-team coach Chris Morgan, who arrived at the club from Sheffield United on Wednesday.
Tickets remain available for the match, with the Proact Stadium ticket office open from 8:30am until kick-off on matchday for ticket sales.
The Spireites face a defensive shortage with Ian Evatt picking up an Achilles injury in Monday's Coventry City match, and Richard Wood being recalled from his loan spell by parent club Rotherham United.
Charlie Raglan is rated as being touch-and-go in his race for fitness, but won't be risked if playing puts him in danger of a longer lay-off, Wilson saying he's willing to put his faith in rookie defender Laurence Maguire if necessary.
In midfield Dan Gardner is fit to return after a groin complaint saw him substituted early on Boxing Day and miss out on Monday.
The Shrews will be missing winger Sullay Kaikai after he was recalled from his loan at the New Meadow by Crystal Palace, and Shrewsbury are also without long-term injury victim midfielder James Wesolowski.
Better news could come in the goalkeeping position, with Jayson Leutwiler a possible returnee after suffering a broken nose in early December, if he doesn't make it Mark Halstead will continue to deputise between the sticks.
The Spireites snapped their losing streak in Wilson's first game at the helm, and will be targeting Saturday's match with the Shrews as an opportunity to get 2016 off to a winning start and help revitalise their season.
Shrewsbury's last-minute 2-1 Monday win at Crewe Alexandra hoisted them two points above of the Spireites, as they currently reside in 17th place in Sky Bet League 1, the Spireites just a point above the bottom four.
After promotion last season, the Shrews have had a rollercoaster return to the third tier, at one point going on an 18-game stretch without a draw but with two wins in their last four outings to move themselves three points above the drop zone.
From the Dugout
Wilson spoke of the Shrewsbury challenge in his pre-match press conference, and knows that his side face a difficult task if they're to get anything from Saturday's game.
"If there are any easy pickings I'd like to know about them, because I've never played them. There's always something to play for in football nowadays.
"This weekend, from our point of view, it's about how we approach it and if we can win it would be a massive lift.
"If we took four points from two home games that's a good start for us and if we can start getting some wins and scoring some goals that would be a big boost for us.
"It will be a tough one, they've got some very good players in the squad as well as some experience, which is always handy.
"Now we're going into the second half of the season and some teams that you expect to be challenging at the top fall away and the teams that have been told they'll be relegated creep up so let's hope that we will see a change in our fortunes as well."
Spireites from around the world can follow all the action, even if they're not lucky enough to get to the Proact on Saturday afternoon.
There will be love and full commentary on Spireites PlayerHD, minute-by-minute coverage on Twitter, images and updates on Facebook and Instagram and full post-match reaction over the weekend.