After battling for a point against Colchester United on Tuesday, the Spireites now need to fight equally as hard to overcome another bottom four side in Crewe Alexandra.
The Spireites were reduced to ten men just 17 minutes into the game midweek but were still able to rally from behind to secure a much-needed result, with more now needed; starting with Saturday's Alex visit.
Tickets are available for supporters from 9am at the Proact Stadium ticket office, with supporters also able to purchase online here
and collect at the stadium before kick-off.
The Spireites will be without their captain, Gary Liddle, after the midfielder was sent off at Colchester and, with the club losing an appeal, he now faces a three-match suspension, starting with Saturday's match.
Also missing is defender Liam O'Neil who was knocked unconscious in last weekend's match with Burton Albion and needs a week or two to recover and be ready for selection again.
However, manager Danny Wilson moved to bring two new faces in this week and both on loan defender Declan John and striker Jordan Slew are fit and clear to feature against on Saturday.
Crewe are without on-loan striker Ryan Seager, who was injured at Rochdale on Tuesday, a situation that could see Alex manager Steve Davis intriguingly turn to Callum Saunders, son of former Spireites manager Dean.
The Spireites brought to an end their four-game losing streak in determined fashion in the undermanned 1-1 draw with Colchester midweek, but know that wins are necessary - especially at home where only three wins have so far been recorded this season - in the attempt to stave off relegation.
Crewe will visit the Proact looking to maintain the second longest unbeaten streak in Sky Bet League 1, behind only Wigan Athletic. Their six-match run contains five draws with the latest an impressive comeback from two goals down at Rochdale on Tuesday.
The midweek result hopped the Spireites a point out of the bottom four with the Alex three points behind them but with plenty of experience in escaping relegation scraps.
From the Dugout
Speaking in his pre-match press conference Wilson praised his side's resolve and attitude in Essex and explained that more of the same will be required this weekend.
"The players had a more ambitious approach in the second half and were quite unlucky at times - maybe we could have nicked it.
"The approach will be no different against Crewe, we know we've got to win the game and we're not going to wait and see what happens, we're going to make things happen. Hopefully at quarter to five we'll have three points and will be looking forward to the next one."
With the expectation now placed upon Saturday's hosts, Wilson says that it is a pressure that his squad must revel in.
He said: "I think it's important that the players do understand the pressure they're under and are unable to embrace it. Pressure can sometimes frighten people, sometimes it can excite people - we've got to find it exciting.
"When we're going into games and the adrenaline's pumping that should be great for players, if we can produce that for the players but then still have a calmness about the play then that's the type of approach that we need."
The Chesterfield manager has seen the Alex play in recent weeks and knows that they'll provide a stern test at the Proact.
"I've been over to watch them on two of the last three occasions they've played and in both cases the opposition could have scored quite a few goals - but Crewe stuck in there," he said.
"The good thing from Steve Davis's point of view is that they can build on that and gain confidence.
"On their day they have players that can change games, but then I think every team in the league has that. That's why the league's so nip and tuck."
As ever, there will be a variety of ways to follow the action wherever you are in the world on Saturday.
There will be live and full commentary on PlayerHD, minute-by-minute tweets on the official Twitter page here as well as Facebook and Instagram updates.