After dropping into the relegation zone it's time for Chesterfield to take survival by the horns, as they travel to strugglers Colchester United aiming to burst back into form.
Friday night's narrow loss at league leaders Burton Albion needs to be put aside as the Spireites go from top to bottom when on Tuesday night they make the long trip to the table propping U's.
Spireites will be able to buy tickets on matchday at Colchester, with details and prices available here.
After his worrying neck injury at Burton Liam O'Neil looks set to miss two weeks while he recovers, the more important news being that he has been given a clean bill of health after a night of tests in hospital on Friday night.
Strikers Lee Novak (illness) and Sylvan Ebanks-Blake (hamstring) are both close to a first team return and have travelled down to Essex ahead of late fitness tests on Tuesday.
Colchester boss Kevin Keen has his own injury problems with Alex Wynter still progressing from a bout of concussion and striker Marvin Sordell battling back from an ankle injury.
Centre midfielder Alex Gilbey misses out after his red card against Southend United ten days ago.
Danny Wilson's men are looking to pick themselves up from four successive defeats, that the last three have been slender one-goal losses shows the team's competitiveness but also the lack of cutting edge going forwards.
The Pirelli Stadium loss coupled with results elsewhere on Saturday saw the Spireites drop in the bottom four for the first time this season, with Wilson saying that the squad are fully aware of their place in a relegation battle.
Colchester however are on an even leaner run of form, with their last league success not until all the way back in mid-October and stretching back as many as 16 games.
The U's have shown more of their mettle in this season's FA Cup and it's from that competition that their last win came; seven games ago at home to Championship side Charlton Athletic.
From the Dugout
Ahead of the encounter at the Weston Homes Community Stadium Wilson explained that he was well aware of the importance of gaining points from the fixture.
He said: "You don't want to be at the bottom of the league fighting, but we are and that means that the game could pan out to be a six-pointer for us.
"If we can go down there and get the three points that will set us up very well for this Saturday and the game against Crewe.
"We know we're going to have to be at our best to get something. Away from home it's never easy anyway and Colchester with have everything to play for from their point of view so it will be a tough encounter."
Asked if there was any chance of his side sitting back tentatively the Spireites manager told supporters that the team will be going all-out for an away win.
"We'll be going for it," he said. "I don't think we can afford to sit back and hope that we don't concede because that makes it a certainty that you do concede.
"We have to go on the offensive and be very positive in our approach. We'll be going there to win the game and hopefully get some confidence for the next game as well."
With the long trip making travel difficult for many Spireites on Tuesday the CFC official channels will be making sure you stay completely up-to-date with all the action.
We'll have live Twitter coverage, Facebook and Instagram updates as well as exclusive commentary on PlayerHD.