The Spireites go hunting a third straight win as they host relegation rivals Blackpool in a hotly-anticipated Sky Bet League 1 clash at the Proact.
Saturday's win at high-flying Gillingham rounded off a good ten days for the Spireites and the challenge now is to continue the upturn in home form after a home win in their last Proact encounter and club the squad away from danger.
Fans can buy tickets for the game from 9am at the ticket office right up to kick-off, with tickets also available over the phone and online.
Danny Wilson reported in his pre-match press conference that his squad came through their Priestfield clash without any new injury worries, with the hours between that and Tuesday's game being used mainly for rest and recuperation.
Midfielder Chris Herd will again be absent for the match with the Tangerines and is hoped to be ready for the weekend, while Gary Liddle serves the final game of his three-match suspension on Tuesday night.
On-loan Blackpool striker Uche Ikpeazu could make his fourth appearance against the Spireites in little over a year - and for a fourth different club - if selected. The 21-year-old has already played against Chesterfield for Doncaster Rovers, Crewe Alexandra and Port Vale since January 2015.
The second half of February held contrasting fortunes for the two sides, as while Chesterfield were picking up seven crucial points in the hunt for Sky Bet League 1 safety Blackpool were sucked back down towards the bottom four.
Saturday's fine win away at third-place Gillingham was the Spireites' second on the spin and also saw the extension of the top two's scoring runs; Sylvan Ebanks-Blake scoring his second in two games while partner Lee Novak scored a screamer for his eighth goal in his last nine outings.
On the other hand, a draw and three losses, the latest a 1-0 home loss to Bradford City on Saturday, have seen the Tangerines fall to within goal difference of the relegation places, now sitting three points behind the Spireites.
From the Dugout
Manager Wilson is looking for his side to come out of the traps quickly and make sure the visitors are kept in their downbeat frame of mind.
"It's a mental state," he said. "They've come off the back of a home defeat and they'll be sore about that. It's now about how they get over it, I'm hoping that the hangover lasts a little bit longer.
"Hopefully we're in a bit of an ascendancy at this moment in time, we need to get out on the front foot, get them on the back foot straight away and see whether they're still feeling sorry for themselves.
"I think it will be a tough game, they'll be very disciplined, very strong and difficult to break down. That may be frustrating at times from our perspective but we'll just have to be patient."
Wilson his often spoken in recent weeks of the importance of confidence and he says that with the help of the Proact support his squad can go out relaxed and ready to win another match.
"I've said before that the home form has been poor this season and that's reflected in where we are. If the home form had been good we wouldn't be where we are.
"But it's getting a bit better, we're getting stronger and more confident at home, the players are relaxing a little bit more and not up tight as I think they have been in some games this season.
"The fans help with that and the way they get behind the players helps them relax and go and play in the manner that we can play."
It should be a great night at the Proact on Wednesday, but if you can't be there in person stay tuned (or tuned in!) to our media channels to make sure you know about every kick.