The Spireites look to hop straight back onto the horse following their FA Cup exit as they head into their last remaining cup competition away at Rochdale.
A win at Spotland would take the Spireites to within three victories of a place at Wembley in April, with round three of the competition a free draw and not regionalised.
Spireites supporters can buy on the day at Spotland, with no tickets available for purchase from the Proact ahead of the fixtures. For prices and further details, click here.
With the Spireites having to persevere with an injury-ravaged squad, there is little room for Danny Wilson to make wholesale changes for the trip to Lancashire, the manager stressing he'll play a strong team for the game.
Defenders Paul McGinn and Sam Hird are getting closer to fitness but the match comes to early for the pair, while the now-training Angel Martinez remains some weeks away from a first-team appearance.
Dale have been boosted ahead of the game by the news of midfielder Joe Thompson signing a new deal with the club over the weekend. The 27-year-old came through the academy at Spotland and after four years away rejoined the club in the summer.
The Spireites' recent run of good form was burst completely by Wycombe's dominant 5-0 win at the Proact in the FA Cup second round tie on Saturday.
With just one route to cup glory now remaining, the Spireites will be looking to move beyond the Checkatrade Trophy second round and make the most of their opportunity after coming through their three-game group section.
After going through in the FA Cup away at League Two high-fliers Carlisle United at the weekend, Rochdale welcome Chesterfield in fine fettle, having won six of their last nine matches in all competitions.
Keith Hill's men made it this far after getting through a group containing Hartlepool, Notts County and Sunderland U21s, winning two games and drawing against the Black Cats, before picking up a bonus point by winning the subsequent penalty shoot-out.
From the Dugout
Speaking about the tie, manager Wilson said he'll be fielding a team that is strong enough to win through at a difficult place to get a result.
"We'll be trying to win the game, of course we will," he said." It's a competition we'd like to say in for as long as we can.
"Whether or not we'll have to make changes, we'll have to wait and see, but we'll certainly put a team out as strong as we can."
We'll have our usual media coverage from Spotland for the game: including live commentary on PlayerHD, as well as coverage across Twitter, Facebook, Instagram and the offcial website.