The Spireites look to build on Saturday's excellent victory at Walsall when they entertain another form side, Southend United, on Tuesday night.
Saturday's win was the Spireites' fourth away success, but with just one win at the Proact Stadium this term Dean Saunders's men face an important week with the visits of the Shrimpers and then Scunthorpe United on Saturday.
Saturday goalscorer Ian Evatt is available to play after an administrative error at Walsall almost cost him a suspension in what would have been fifth yellow card of the season.
Instead referee Chris Kavanagh was able to revert the booking to the guilty party, Sam Morsy, and with it re-instate Evatt's availability for the game.
Shrimpers midfielder Gary Deegan returns to first team contention after serving a suspension at the weekend, while his replacement Anthony Wordsworth could retain his place after a goalscoring return against Barnsley.
Michael Timlin is also likely to stay in the engine room after being a doubt for Saturday's match at Roots Hall with a rib injury.
The Spireites haven’t won at home since the opening game of the season but come into the game on the back of a fantastic 2-1 away win to then league-leaders Walsall.
Twice Chesterfield have let two-goal leads slip and three times conceded in injury time at the Proact, and can ill-afford for the trend to continue if they are to improve their home record.
Southend have made a good start to life in League One, winning five out of their last six games in the league, a run that followed a slow start to the campaign where they took six games to record their first win.
On Saturday the Shrimpers conceded a first half goal to Barnsley but fought back to record a 2-1 win with goals from Wordsworth and Luke Prosser.
From the Dugout
Assistant manager Brian Carey spoke to PlayerHD ahead of the game and stressed the importance of concentrating on the team's strengths in order to improve the Spireites' home form.
He said: “The way the season has gone so far, it has been up and down. We have been pleased with the performances and I don’t think we have got the results that we've deserved, definitely at home.
“The away form has been good. What we have to do is concentrate on what we are about and what we do well to progress.
“We’ve got to take this and try and get as many points as we can in October and we won’t look further than that. I was surprised to hear about the poor run of results last October but it shows what can happen, if you get a bad run of form you can still recover."
Southend are currently just one spot and goal difference away from the play-off places, and striker Joe Pigott is certainly one to look out for, the on-loan Charlton striker bagging five goals this campaign already.
“You do have to bear in mind the opposition and what they are about," said Carey. "We look at the strengths and weaknesses and try to nullify any strength that they may have, and capitalise on any weaknesses they may have.
“Certain games we approach differently, we look at all opposition and hopefully we can come out on top and do what we have been doing away from home back here at the Proact.”
As ever, you can follow all the action with live commentary anywhere in the world on PlayerHD, follow minute-by-minute coverage on Twitter and with score updates on Facebook.