Scunthorpe claimed a 3-0 Proact win as a moment changed the entire game when the Spireites lost a man and conceded a penalty in one almighty second half blow, the game goal-less at the time.The encounter changed in a moment 55 minutes in when Dan Jones received an instant dismisal and Scunthorpe a penalty as Paddy Madden was fouled by the last man. Madden then took the spot-kick himself to open the scoring.
Former Chesterfield striker Gary McSheffrey added a second with a brilliant volley before Madden grabbed his second with a low shot,
Dan Gardner next went close for the hosts after Luke Daniels had punched away a Jones cross, the ball falling to the Chesterfield number seven who drilled low but saw his effort blocked.
The match became even with Scunthorpe showing attacking intent of their own, striker Paddy Madden had the chance to volley a freekick at the back post, but Lee was equal to it.
Midway through the half the visitors had their best chance yet when McSheffrey arrived in space to head from seven yards, but his downwards effort was a foot wide when he would have backed himself to score.
The Spireites 'keeper had to be sharp again after 33 minutes as McSheffrey shot low after being set up by Tommy Rowe, Lee able to get a strong hand to it and keep it out.
Soon Jay O'Shea went close for the hosts as the ball broke to him 25 yards out and his stinging shot deflected narrowly over the Scunthorpe bar.
Lee then kept his side level with a magnificent double save, first from an Iron freekick and then, with players lining up to finish, he spread himself to brilliantly save the follow up.
Novak found space and very nearly strike partner Ebanks-Blake with a low ball across the six yard box late in the half, but a defensive interception ensured the teams completed the first 45 minutes on level terms.
A strong opening five minutes to the second period from the Spireites saw Novak fire over from long range and O'Shea have a shot closer in blocked as he turned sharply, but no way through for the Spireites.
Ten minutes into the and a decisive moment took place as Madden rushed in on goal, was fouled by Jones in the area, who was also last man, with the referee giving the visitors a penalty and Jones a straight red card.
The full punishment was then exerted by Madden as he rolled home his effrt for the penalty spot.
Scunthorpe were soon two to the good after a stunning McSheffrey strike, the forward controlling a powerful volley from 22 yards and giving Lee no chance - increasing the mountain facing the home side.
O'Shea almost pulled one back straight away for the hosts, but his clever 20-yard shot whislted narrowly wide of Daniels's far post.
It was the Irishman again who went close twice, he first hit the crossbar with a dipping freekick, the 'keeper beaten, before seeing a deflected effort go straight at Daniel when either side of him would have given the hosts hope.
The home chances of an unlikely comeback took a terminal blow as Scunthorpe broke with 15 left on the clock and that man Madden again claimed his second with a low half-volley that beat the unsighted Lee.
Scunthorpe United: Madden 56' (pen) 78', McSheffrey 63'
Chesterfield: Jones 55'
Attendance: 6,340 (635 away fans)