Chesterfield make the short journey north into South Yorkshire as they take on Doncaster Rovers at the Keepmoat Stadium on Tuesday night.
It's also a first trip back to Doncaster Rovers for Spireites manager Dean Saunders, who had a successful spell as manager at the Keepmoat between 2011 and 2013.
The Spireites have no new injury concerns after playing 90 minutes in the snow at Vale Park on Saturday, and are boosted by the return of Mani Dieseruvwe who missed out at the weekend with an infection.
Teenage striker Rai Simons further pushed his case for more first team game time after a superbly-taken injury time consolation at Port Vale.
Doncaster's on-loan striker Keshi Anderson suffered a suspected broken leg after coming on as a substitute on Saturday, with the club said to be in the emergency loan market ahead of the window closing on Wednesday.
Eight other Rovers missed the weekend match through illness and while Richie Wellens is expected to recover in time for tonight's match, the likes of Luke McCullogh, Paul Keegan, Richard Chaplow and Rob Jones are less likely to make it.
Back-to-back losses have dented the Spireites' recent progress up the Sky Bet League 1 table, and in a congested division dips in form need to be ended quickly.
The task for the Spireites now is to recover from Saturday's disappointment and get their away form back on track 25 miles up the road in South Yorkshire.
With results leading to the exit of former Spireites hero Danny Wilson at the Keepmoat helm, incoming manager Darren Ferguson has presided over four wins and three losses in his five weeks in charge of Rovers, including a three-game winning streak before the weekend's 2-0 home loss to Rochdale.
Prior to conceding two late goals to Dale, Rovers had gone over 400 minutes without letting a goal in, changing their formation to a 3-5-2 under Ferguson in the quest for clean sheets.
From the Dugout
Ahead of the Keepmoat encounter Saunders sat down with PlayerHD to discuss the upcoming fixture, pinpointing the strength of their squad.
He said: "They've got a lot of players and nearly all of them have played in the league above.
"I know Darren, he gets his teams play attacking, attractive football. We know what their weaknesses are and we know what their strengths are, so I'll have to pick the team to try and hurt them.
"Do we change for them or do they change to suit our system? You've got to win the ball first, you've got to be more determined and you've got to work hard to stop them, get the ball and show them the talent that we've got.
"If you give the ball away all the time no system works, but if you keep the ball it can work. It's about having good players who can keep the ball and make the system work."
Saunders went on to say that he enjoyed his time with Doncaster, but that any sentimentality will be lost when the teams kick-off at the Keepmoat.
"I enjoyed it there and left there on good terms when we were top of the league and flying," he said. "That doesn't mean anything now as I'm Chesterfield manager and we're going there to win.
"It's a great place and I loved it, so I'm looking forward to going back."
Spireites can follow every kick of the action wherever in the wide world they are. There'll be live and full commentary on PlayerHD, minute-by-minute coverage on Twitter as well as updates and photos on Facebook and Instagram.