'Ernie Moss Day' will be celebrated this coming Saturday when the Spireites face another of the legendary striker's former clubs, Port Vale.
Ernie, who is the club's all-time record goalscorer with 191 goals, is now suffering from a form of dementia known as Pick's Disease.
A series of specially produced items will be on sale to mark the day, including a limited edition badge and an exclusive ale. A special edition of the Inspire matchday programme will also be produced, featuring a poster showing an iconic image of Ernie in action and tributes from former colleagues.
A total of 750 badges have been produced with the first one being presented to Ernie, who made 749 appearances in his career. A minimum donation of £3 will be requested for a badge, with all proceeds going to a dementia charity. Bucket collections around the stadium will raise further funds for the charity.
Chesterfield-based Brampton Brewery have brewed an 'Ernie 8' ale, which will be on sale on Saturday. Chris Radford, Brampton Brewery's managing director, has kindly agreed to make a donation to the fundraising initiative for every pint of Ernie 8 purchased on the day.
Ernie, 65, will be joined at the game by family members and a number of friends and former team-mates. Fans will be able to pay tribute to him when he is introduced to the crowd during the half-time interval.
Spireites chief executive Chris Turner said: "Everyone at the club was saddened to hear about Ernie's condition and we wanted to show our support for him and his family while raising money for an appropriate cause in the process.
"We felt it was appropriate to stage the day when we faced Port Vale as he is also highly regarded there. He is one of the most popular players in the history of the club and his goalscoring exploits will never be forgotten."