The Spireites head back into the league at Bury looking to improve their recent form ahead of the all-important Christmas run of fixtures.
Sam Morsy's late equaliser secured an FA Cup replay in a much-improved draw with Walsall last Saturday and caretaker manager Mark Smith will look to continue the progression at Giggs Lane.
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Chesterfield will be without defender Richard Wood who picked up a minor adductor problem in the Cup tie with Walsall and has temporarily returned to parent club Rotherham United to receive treatment.
Striker Lee Novak is a doubt after limping out of training on Thursday, though Smith stated that he's optimistic that Novak will be fine to make the squad for the match in Greater Manchester.
Bury could be without key midfielder Danny Mayor for the match, after the influential former Preston man limped off with a rolled ankle during the first half of last Saturday's 1-0 Cup win at Rochdale.
Andrew Tutte and Jacob Mellis are also injured for the Shakers, while on-loan 'keeper Daniel Bachmann will remain in goal with usual first-choice stopper Rob Lainton missing the last month or so.
Right-back Joe Riley is a doubt for the game after missing with a knee injury last weekend, with Craig Jones likely to be his replacement again if Riley is unable to play.
The Spireites are six weeks without a Sky Bet League 1 victory, but showed signs of a revival after the change in management during the match with Walsall last Saturday.
Bury sit tenth in the table but after an amazing seven-game winning run through September have brought a mixed run of results into the colder months, with three losses and a win over Burton in their last four league games.
The Shakers did secure FA Cup progression and a third round home tie with Bradford City after a hard-fought 1-0 win over local rivals Rochdale at Spotland, midfielder Danny Rose settling the game with an early goal.
From the Dugout
Smith spoke about Bury strengths and the positive approach he intends to take for the match in his pre-match press conference.
"I've spoken to Mitch (Paul Mitchell) about them and he's seen them a couple of times," he said. "They've got some players that can hurt you and we'll have to be on our toes - but then I think we've got players who I think can hurt them as well.
"We've got to go there and impose ourselves on them. I can't see the point of going there and being negative. so we'll take the game to them and see what happens."
With the hunt ongoing for a new permanent manager, Smith also fed back on his knowledge of the ongoing process at the club.
"I was asked last week to take the reins and to keep everything going," he explained. "There was no rush to appoint a manager then and as far as I know nothing's changed.
"I'm sure that with the next couple of results it'll intensify the search for the next man or it will show us that things are okay and we can take our time.
"I assume I'll still be in charge for the week after against Bradford. Whatever happens, I'll be staying relaxed and we'll keep going."
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