The Spireites will look to carry their FA Cup form into the league with an away trip to bottom side Crewe Alexandra at 3pm on Saturday.
The Railwaymen may hold a lowly current league position, but have stopped the rot after, at one point this season, losing ten out of 12 matches.
In fact, contrasting recent form has seem tomorrow's hosts lose just one of their last six matches, a narrow 1-0 defeat to Sheffield United.
Furthermore, Crewe have tightened things up at the back, keeping clean sheets and making the opposition work harder to score past them.
At the attacking end, the Alex have struggled for goals this term and will face Chesterfield without top-scorer Marcus Haber, who will miss the game due to an international commitments with Canada.
Crewe are also unlikely to risk their captain Mark Tootle for the Gresty Road fixture. The right back has suffered from illness over the past fortnight and lost weight, with 18 year-old James Baillie likely to once again deputise.
The Spireites camp is suddenly brimming with confidence again after the 6-0 cup victory, when Eoin Doyle, Jay O'Shea, Sam Clucas and Gary Roberts got their names on the score sheet.
There has also been positive injury news with Roberts coming through the Braintree Town match unscathed after a series of hamstring injuries.
Looking ahead to the game, manager Paul Cook predicts a hard fought match that will bear little relation to the League One table.
He said: "Crewe beat Peterborough United at home a couple of Tuesday nights ago and anyone who knows anything about Peterborough knows how strong a team they are.
"These are difficult games, you don't play football on paper you play it on grass against 11 men and you must be at it. If you're attitude's right you end up getting good results like we did at Braintree.
"Going there tomorrow we must show the right attitude and not listen to the fact that they're bottom of the league. We must go there like it's the biggest game of the weekend."
After a good week on the training ground, the manager is excited to be back in league action - and has a great deal of respect for the footballing ethos held at Saturday's opponents.
Cook said: "We've prepared well, we're looking forward to the game and we respect Crewe as a team.
"Over the years they've always played good football, they've had promotion winning teams and they've had relegation teams.
"What they do is continually have the same philosophy at the club and it's a philosophy that's seen them sell players regularly, have a cracking stadium and training base and build a rock steady club."
You can follow the match on Facebook and via minute-by-minute Twitter coverage, while Spireites Player subscribers can listen to full commentary of the match on the Spireites Player site.