The Spireites face one of their longer haul away trips as they travel to seventeenth-placed Crawley Town for the first ever meeting between the clubs.
Chesterfield hauled themselves out of their seven game winless run thanks to the 2-1 derby win over Barnsley last weekend, and Crawley Town will be hoping to do something similar when they host the Spireites on Saturday.
The Reds have gone six games since their last victory, a 1-0 win over Walsall, a streak consisting of two cup defeats sandwiched by four League 1 draws.
However, their last league outing against Scunthorpe United displayed considerable spirit, coming from two goals down to snatch a 2-2 draw late on.
In team news, tough-tackling midfielder Sam Morsy returns to the Spireites squad for the match, having missed the win over Barnsley through suspension, while Ollie Banks - who started in Morsy's place last weekend - has this week moved on loan to Northampton Town.
Defender Sam Hird is making good progress from his long-term knee injury but has not travelled with the team and is being pencilled in for a squad return next week for the FA Cup tie with MK Dons.
Meanwhile, Austrian centre back Georg Margreitter is now fully fit and will compete with Charlie Raglan for one central defensive berth alongside captain Ian Evatt.
For Crawley, much-travelled striker Izale McLeod has made a goalscoring start to his time with the club, his eleventh in the professional game. The former MK Dons target man has seven goals to his name so far this campaign and he tops the Red Devils' scoring list.
A second Red to look out for is former Swansea City attacker Gwion Williams. The 21 year-old can play in the hole behind the strikers or out on the wing and has impressed since making his loan move to the Broadfield Stadium permanent during the summer.
Elsewhere, loan signing Shaun Miller goes straight into the matchday squad following the striker's arrival from Coventry City,
Speaking to Spireites Player before the game, assistant manager Leam Richardson was looking forward to a game at a ground he knows well.
He said: "Crawley is a very good place to go, I've always enjoyed going down there.
"They will certainly offer a very good game for us, we're expecting this, they've had some great results from Oldham and Scunthorpe."
Despite Crawley's sluggish recent run of form, Richardson says the management team are anticipating another touch League 1 fixture.
He said: "We're expecting them to come out and play to get the win and to score goals. It'll be a great game."
You can follow the match tomorrow via minute-by-minute text coverage on Twitter, score updates on Facebook and full live match commentary on Spireites Player.