Assistant-manager Leam Richardson expects Portsmouth to provide the Spireites with a tough test in Monday night's televised game at the Proact.
Richie Barker's men currently find themselves positioned near the bottom of the table but Richardson is aware of their strengths and the threat they pose. He said: "They're a very good team with very good individual players and Richie is a good manager with some good staff. We expect a really, really tough game.
"I think it will be entertaining. They've got lads down the flanks who can open doors. They need results, as everybody does as this time of the season, so I think it will be a great game for the neutrals."
The Spireites are a point clear of promotion rivals Scunthorpe United and Rochdale at the top of the Sky Bet League 2 table, with a game in hand on the former team. Confidence is high following Tuesday night's impressive 4-1 win at Cheltenham Town, with just one defeat in their last eight league games.
Richardson hopes that they can continue that good run of form in front of a live TV audience. "The lads know what's expected of them so hopefully we'll maintain our standards and come out with a positive result," he said.
With the Johnstone's Paint Trophy final at Wembley at the end of the month, March promises to be a crucial period, as Richardson acknowledges. "We've got a lot of tough games coming up before that but it's at the back of your mind because it's something you look forward to," he said. "The closer it gets to the match, we'll turn our focus to that."
See the full interview on Spireites Player.