Rochdale will visit the Proact Stadium on Tuesday night in the area quarter final of the 2013/14 Johnstone's Paint Trophy.
Chesterfield received a bye in the first round of this season's competition before defeating local rivals Mansfield Town at the One Call Stadium in the second round.
The Spireites are currently unbeaten in four games, defeating Daventry Town 2-0 on Saturday in their last outing at the Proact Stadium.
Dale also avoided the first round of the Johnstone's Paint Trophy with a first round bye before beating Port Vale 1-0 at Vale Park to progress to the area quarter finals.
The Greater Manchester side come into Tuesday's game on the back of a 2-0 victory at Torquay United in the FA Cup on Saturday afternoon.
Before the weekend's game however, Dale had suffered back-to-back defeats at the hands of Dagenham & Redbridge and AFC Wimbledon in Sky Bet League 2.
Chesterfield and Rochdale have already met in the 2013/14 season, sharing the points in a thrilling 2-2 draw at Spotland Stadium in August this year.
The last game between these sides at the Proact Stadium ended with a last minute Jack Lester strike cancelling out a Andrew Tutte goal as the sides drew 1-1 in August 2012.
Sam Morsy picked up an MCL injury against Bristol Rovers and is not expected to return until the new year.
Nathan Smith is unavailable for selection as he is suffering from a recurrence of the ankle injury that has kept him out of action for the majority of the 2013/14 season.
After only featuring on the bench during Saturday's FA Cup against Daventry Town, Ritchie Humphreys makes a full return and is available for Tuesday night's game.
Peter Cavanagh (achilles) completed 90 minutes in a behind-closed-doors game last week, but won't be available for another four weeks and misses out on Tuesday.
Chesterfield: 10/11 Draw: 5/2 Rochdale: 3/1
Skybet have Chesterfield as favourites going into Tuesday's game but believe Rochdale have every chance of progressing to the next round.
(Odds accurate as of 1pm on Tuesday, November 12)
If you can't make tonight's game you can follow the action through live commentary on Spireites Player and minute-by-minute text updates on Chesterfield's official Twitter account.
Spireites Player is also the best place for all post match reaction and highlights after the final whistle and throughout the week.