Chesterfield lost 2-1 at The Merseyrail Community Stadium against Paul Cook’s former side, Southport.
The first half started slowly, with neither side keeping the ball well but it was Chesterfield that had the best of the chances. Liam Cooper tried his luck from 35 yards only to see his shot fizz wide, whilst good play from Talbot down the right hand side led to a chance for Gary Roberts but he put his shot just past the far post.
The breakthrough for the Spireites came in the form of a penalty on 19 minutes as Darikwa was put through but was brought down by Luke George. Marc Richards stepped up from 12 yards to neatly tuck the ball in the right-hand side of the goal past Danny Hurst.
Southport then came back after the restart and managed to draw level with a penalty of their own on 24 minutes. Aaron Chalmers played in Danny Hattersley who was taken out by an onrushing Tommy Lee. Hattersley dusted himself off and sent Lee the wrong way to equalise for the Conference Premier side.
Chesterfield had their chances before the break with Richards hitting a shot straight at the goalkeeper and another penalty appeal turned down by the referee but Southport also could have took the lead with Talbot stopping a certain goal, with Chris Almond being prevented from scoring into an open goal.
The second half started brightly for The Spireites, with a lovely lay-off from Roberts putting in Richards who again struck straight at Hurst and Morsy put the follow-up over the bar.
However, it was Southport who went in front on 67 mins when Almond put in substitute Yamen Osawe who turned Talbot before pulling back for Almond who simply stroked it into the goal.
Chesterfield sub Armand Gunanduillet almost hit back immediately after a ball from Roberts but his shot hit the side netting.
The Lancashire club kept possession well for most of the second half, with Almond almost scoring again bar a save from Lee, but poor defensive work almost put through Gnanduillet but his shot was saved easily by Hurst.
Southport were awarded another penalty after Nathan Smith brought down Matty Harris, but sub goalkeeper Aaron Chapman saved to his left from Chalmers.
Chesterfield will feel that they could have gotten more out of the game but Southport worked hard all game and deserved their victory.
Chesterfield: Lee (Chapman 75'), Talbot, Hird (Brown 72'), Cooper, Humphreys (Smith 62'); Morsy (Togwell 54'), Ryan (Bencherif 69'); Darikwa (Doyle 54'), O'Shea, Roberts (Devitt 72'); Richards (Gnanduillet 54').