Manager Paul Cook has suffered a couple of injury blows to key players in the last week.
Despite passing a late fitness test, striker Marc Richards limped off after 20 minutes against AFC Wimbledon at the weekend and Tendayi Darikwa faces up to five weeks out with a double hernia.
Although Cook acknowledges that these are big players to lose, he sees it as a great opportunity for another player to take his chance.
He said: "I think in football as a manager you have got to be cold, calculated and have belief in all of your players. I said to the subs who never got on today [against Wimbledon], as disappointed as you are, to be at this club we must think you can go in the team because if we don't, not being disrespectful, we won't have them at the club if at all possible.
"He [Marc Richards] felt it yesterday and stopped training immediately. I don't risk players, i'm not a manager who believes today is a massive game for the club and you risk Marc Richards and he's out for six weeks. It doesn't work for me.
"So today, with all due respect to Marc [Richards] he comes out but it offers an opportunity for other people. The same with Tendayi, we miss big players but they are all big players."